Kicking off at 7pm at the Whites' home ground, David Lee's side will be looking to build off the back of their victory against Nottingham Forest last time out.
They are unbeaten on their own soil meanwhile, having won four out of five games in front of their own supporters so far this term.
Their form in general has seen them win seven, draw one and lose three matches to leave them sitting second in the table.
Wednesday however have won four, drawn three and lost four games and sit seventh with 15 points from 11 outings.
Last time out, they lost 4-2 with their Burnley counterparts.